Genetic Susceptibility to Atopic Dermatitis
نویسندگان
چکیده
منابع مشابه
Genetic susceptibility to atopic dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an increasing prevalence in industrialized countries. AD belongs to the group of allergic disorders that includes food allergy, allergic rhinitis, and asthma. A multifactorial background for AD has been suggested, with genetic as well as environmental factors influencing disease development. Recent breakthroughs in genetic meth...
متن کاملGenetic variation in the inflammasome and atopic dermatitis susceptibility.
2 Atopic dermatitis (AD) is a common chronic inflammatory skin disease. The pathophysiological factors include genetic predisposition to skin barrier defects, dysregulated immunity and hypersensitive allergen response (Novak and Simon, 2011). The high levels of proinflammatory cytokines in AD initiate and maintain the inflammation (Bieber, 2008) and mediates cross-talk between innate and adapti...
متن کاملGenetic aspects of atopy and atopic dermatitis.
This review presents updated evidence on the genetic basis of atopy and atopic dermatitis. The etiology of atopic processes remains partially unknown but is likely to result from multifactorial inheritance, with an interaction between genetic and environmental factors. It seems that at least two major mechanisms, non-antigen specific and antigen specific, regulate the immune response to environ...
متن کاملGenetic and epigenetic studies of atopic dermatitis
BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex interaction of genetic, immune and environmental factors. There have many recent discoveries involving the genetic and epigenetic studies of AD. METHODS A retrospective PubMed search was carried out from June 2009 to June 2016 using the terms "atopic dermatitis", "association", "eczema", "gene", "polymor...
متن کاملORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations
Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2008
ISSN: 1323-8930
DOI: 10.2332/allergolint.r-07-150